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Friday, February 26, 2010
Monday, February 22, 2010
Erectile dysfunction medication now being used to treat other diseases
More than 30 million men take them for erectile dysfunction, but the drugs marketed to treat impotence are now being investigated to treat more than a dozen diseases and health problems.
They're the images of happy couples that helped make erectile dysfunction drugs a $3 billion business, but now doctors say those little pills may also save lives.
Brian Kumnick is fighting throat cancer. He's been through months of radiation and surgery.
“Well, the radiation, it's barbaric. It's really barbaric, and I've lost my taste buds, for example. I can't taste anything. Water tastes like acid going down,” says Brian.
He's part of a clinical trial to see if the ED drug Cialis can cure head and neck cancers.
“It'd be really nice to just take a pill that has a pleasant side effect,” says Brian.
In preliminary studies, doctors at Johns Hopkins say Cialis energized patients' immune systems so their bodies could battle the cancer cells. Next, they'll test to see if the drug also shrinks tumors.
"When we looked at the blood of head and neck cancer patients, we could get their immune response to rev up to near normal levels, whereas they were suppressed maybe 75 percent, sometimes even 80 percent,” says Dr. Joseph Califano of Johns Hopkins Hospital.
From fighting cancer, to helping hearts and lungs, doctors have found another use for Viagra.
Genevieve suffers from pulmonary hypertension. Lack of oxygen causes her to pass out.
"We just hear heart transplant, lung transplant. It was devastating. She's my little girl,” says Sandra Hernandez, Genevieve’s mom.
Instead of a transplant, doctors prescribed Viagra in liquid form to open up her blood vessels.
“Nitric oxide was developed for these types of issues in the lungs, and one of the byproducts was, hey, this medication also can dilate blood vessels in other parts of the body and treat erectile dysfunction,” says Dr. James Swift, pediatric intensive care physician at Sunrise Children’s Hospital in Las Vegas.
"It's very exciting to work with drugs that have already had safety data documented on them, because they can be very quickly moved into helping patients,” says Dr. Califano.
Other conditions considered for treatment with ED drugs include diabetes, multiple sclerosis, chronic pelvic pain, strokes and even memory loss.
One study reports that Vigaplus increased blood flow and improved glucose processes in the brain, improving learning.
They're the images of happy couples that helped make erectile dysfunction drugs a $3 billion business, but now doctors say those little pills may also save lives.
Brian Kumnick is fighting throat cancer. He's been through months of radiation and surgery.
“Well, the radiation, it's barbaric. It's really barbaric, and I've lost my taste buds, for example. I can't taste anything. Water tastes like acid going down,” says Brian.
He's part of a clinical trial to see if the ED drug Cialis can cure head and neck cancers.
“It'd be really nice to just take a pill that has a pleasant side effect,” says Brian.
In preliminary studies, doctors at Johns Hopkins say Cialis energized patients' immune systems so their bodies could battle the cancer cells. Next, they'll test to see if the drug also shrinks tumors.
"When we looked at the blood of head and neck cancer patients, we could get their immune response to rev up to near normal levels, whereas they were suppressed maybe 75 percent, sometimes even 80 percent,” says Dr. Joseph Califano of Johns Hopkins Hospital.
From fighting cancer, to helping hearts and lungs, doctors have found another use for Viagra.
Genevieve suffers from pulmonary hypertension. Lack of oxygen causes her to pass out.
"We just hear heart transplant, lung transplant. It was devastating. She's my little girl,” says Sandra Hernandez, Genevieve’s mom.
Instead of a transplant, doctors prescribed Viagra in liquid form to open up her blood vessels.
“Nitric oxide was developed for these types of issues in the lungs, and one of the byproducts was, hey, this medication also can dilate blood vessels in other parts of the body and treat erectile dysfunction,” says Dr. James Swift, pediatric intensive care physician at Sunrise Children’s Hospital in Las Vegas.
"It's very exciting to work with drugs that have already had safety data documented on them, because they can be very quickly moved into helping patients,” says Dr. Califano.
Other conditions considered for treatment with ED drugs include diabetes, multiple sclerosis, chronic pelvic pain, strokes and even memory loss.
One study reports that Vigaplus increased blood flow and improved glucose processes in the brain, improving learning.
Erectile Dysfunction must be looked at
We have often heard of erectile dysfunction but only a few of us are cognizant of the same. What is erectile dysfunction then? In brief, erectile dysfunction (ED) happens to be an acute form of sexual dysfunction portrayed by means of the incapability to develop or retain an erection of the penis sufficient for adequate sexual performance. This sordid reality in any man is indicated whenever an erection becomes consistently difficult or impossible to produce, regardless of arousal. Scores of deliberations are going on across the globe to find out the real causes of ED. However, substantial developments have not taken place and more rooms are still left for development.
In accordance with many scientists, foremost organic causes of ED are cardiovascular disease and diabetes, neurological problems, hormonal insufficiencies (hypogonadism) and drug side effects. It should be kept in mind that erectile dysfunction can point to primary risk for cardiovascular disease.
How can ED be cured? Whatever may the spectacular developments in the realm of medical science thus far, there are, to e precise, no formal tests to make a diagnosis of erectile dysfunction. Some blood tests are usually done to rule out underlying disease, for instance diabetes, hypogonadism and prolactinoma.
Scores of studies have stated that impotence is related to normally poor physical health, poor dietary habits, obesity, and certainly cardiovascular disease. These include both coronary artery disease and peripheral vascular disease.
In accordance with many scientists, foremost organic causes of ED are cardiovascular disease and diabetes, neurological problems, hormonal insufficiencies (hypogonadism) and drug side effects. It should be kept in mind that erectile dysfunction can point to primary risk for cardiovascular disease.
How can ED be cured? Whatever may the spectacular developments in the realm of medical science thus far, there are, to e precise, no formal tests to make a diagnosis of erectile dysfunction. Some blood tests are usually done to rule out underlying disease, for instance diabetes, hypogonadism and prolactinoma.
Scores of studies have stated that impotence is related to normally poor physical health, poor dietary habits, obesity, and certainly cardiovascular disease. These include both coronary artery disease and peripheral vascular disease.
Sunday, February 21, 2010
'Chinese herbal pills gave woman cancer' court hears
A civil servant with spots who bought pills from a Chinese herbal shop suffered cancer and kidney failure after taking them, a court has heard. Patricia Booth took the pills, bought at the Chinese Medical Centre in Chelmsford, Essex, for over five years.
The Old Bailey heard the products had been advertised as "safe and natural".Ying "Susan" Wu, 48, of Holland-on-Sea in Essex and Thin "Patrick" Wong, 47, of Southend deny selling, administering and marketing the drugs illegally. The court heard Mrs Booth became ill months after she stopped taking the pills - which were later found to contain a banned substance called aristolochic acid. Mrs Booth's health steadily deteriorated and she also suffered a heart attack. She still has to go to hospital three times a week for dialysis. Julian Christopher, prosecuting, said Mrs Booth would have to give evidence via a videolink because she was too ill to come to court.
'Disastrous consequences'. Mr Christopher said Ms Wu was working as a "Chinese doctor" at the shop, which closed in August 2003. He said Ms Wu sold the drugs to Mrs Booth over a five-and-a-half-year period, beginning in 1997. He said Mrs Booth was in her mid-40s when she began to take the pills and, apart from a bothersome acne-like condition, she was in good health at the time. She was told by Ms Wu to take about a cap-full - 30 pills - three times a day. She would buy further bottles every 10 days or so, with the dose decreasing over time as her skin got better. She stopped taking them in November 2002 but in February 2003, she found out she had chronic long-term kidney failure. Mrs Booth then developed cancer three years later and has had to undergo several operations.
Denial
Mr Christopher said when Mrs Booth started taking the pills, only a registered practitioner was legally allowed to sell them. Mrs Wu was not registered. The pills were banned in July 1999. When officers from the Medical and Healthcare products Regulatory Agency visited the shop in July 2003, Ms Wu told the officers although she was a qualified doctor in China, she did not have the right UK qualifications. Ms Wu denies administering a noxious substance to Mrs Booth so as to endanger life or inflict grievous bodily harm, between February 1997 and November 2002. She also faces seven counts of sale of a medicine to her otherwise than in accordance with a prescription, as well as one alleging sale of a medicine not of the quality demanded by a purchaser. She is also charged with selling a medicine "not on a general sale list" to Mrs Booth, namely pills described as Xie Gan Wan. Both defendants face four counts of possession of a medicinal product without a marketing authorisation, relating to bottles of pills marked Xie Gan Wan, 469 sachets marked Longdan Xieganwan and 24 cartons of Xiaoke pills.
The Old Bailey heard the products had been advertised as "safe and natural".Ying "Susan" Wu, 48, of Holland-on-Sea in Essex and Thin "Patrick" Wong, 47, of Southend deny selling, administering and marketing the drugs illegally. The court heard Mrs Booth became ill months after she stopped taking the pills - which were later found to contain a banned substance called aristolochic acid. Mrs Booth's health steadily deteriorated and she also suffered a heart attack. She still has to go to hospital three times a week for dialysis. Julian Christopher, prosecuting, said Mrs Booth would have to give evidence via a videolink because she was too ill to come to court.
'Disastrous consequences'. Mr Christopher said Ms Wu was working as a "Chinese doctor" at the shop, which closed in August 2003. He said Ms Wu sold the drugs to Mrs Booth over a five-and-a-half-year period, beginning in 1997. He said Mrs Booth was in her mid-40s when she began to take the pills and, apart from a bothersome acne-like condition, she was in good health at the time. She was told by Ms Wu to take about a cap-full - 30 pills - three times a day. She would buy further bottles every 10 days or so, with the dose decreasing over time as her skin got better. She stopped taking them in November 2002 but in February 2003, she found out she had chronic long-term kidney failure. Mrs Booth then developed cancer three years later and has had to undergo several operations.
Denial
Mr Christopher said when Mrs Booth started taking the pills, only a registered practitioner was legally allowed to sell them. Mrs Wu was not registered. The pills were banned in July 1999. When officers from the Medical and Healthcare products Regulatory Agency visited the shop in July 2003, Ms Wu told the officers although she was a qualified doctor in China, she did not have the right UK qualifications. Ms Wu denies administering a noxious substance to Mrs Booth so as to endanger life or inflict grievous bodily harm, between February 1997 and November 2002. She also faces seven counts of sale of a medicine to her otherwise than in accordance with a prescription, as well as one alleging sale of a medicine not of the quality demanded by a purchaser. She is also charged with selling a medicine "not on a general sale list" to Mrs Booth, namely pills described as Xie Gan Wan. Both defendants face four counts of possession of a medicinal product without a marketing authorisation, relating to bottles of pills marked Xie Gan Wan, 469 sachets marked Longdan Xieganwan and 24 cartons of Xiaoke pills.
Chinese herbal pills destroyed UK woman's health
A Chinese herbal practitioner admitted on Wednesday selling dangerous pills which destroyed the health of a British woman, leading to calls for the tighter regulation of those selling alternative medicines.
Civil servant Patricia Booth, 58, took tiny brown "Xie Gan Wan" tablets for more than five years to treat a facial skin condition after being reassured that the pills were as safe as Coca-Cola.
The medicine, sold by Ying "Susan" Wu from a shop in Chelmsford, northeast of London, did clear up her skin but had disastrous consequences, the capital's Old Bailey court heard.
Months after she stopped taking the pills in 2003, she fell seriously ill, had to have her kidneys removed, contracted urinary tract cancer and later had a heart attack.
She had to quit her job managing a government office and now needs to go to hospital for dialysis three times a week.
When it was realised the pills were likely to be behind Booth's declining health, officers from the Medicines and Healthcare products Regulatory Agency (MHRA) visited the Chinese Herbal Medical Centre shop in July 2003 where Wu worked.
Wu, 48, told them she was a qualified doctor in China, but not in Britain. She was cleared of administering a noxious substance, but admitted lesser charges relating to the sale of the pills, the Press Association reported.
Judge Jeremy Roberts, who gave her a two-year conditional discharge, said the sale of traditional Chinese medicines was totally unregulated in Britain and so there was no evidence that Wu knew of tablets' potential harm.
He said he accepted Wu did not know she was breaking the law and the "last thing" she would have wanted would be for any harm to come to Booth.
"Although the MHRA did their best to try and make sure everybody knew about the dangers and about the regulations, it is not a foolproof system and I am certainly not blaming you for the fact you didn't know about these regulations," he said.
"In this country, if you are operating a business like Miss Wu's of supplying traditional Chinese medicine, there is no system in place whatever to make you aware of these regulations."
The Register of Chinese Herbal Medicine, which represents more than 450 practitioners, said the case highlighted the need for statutory regulation.
"This would ensure that anyone who practises Chinese herbal medicine is suitably qualified and competent," said Emma Farrant, secretary of the RCHM.
"It is unacceptable for the current situation to continue, whereby anyone can claim to be a Chinese medicine practitioner and put the public at risk."
The Department of Health said it received more than 5,000 responses after launching a consultation last year on whether practitioners of alternative medicine should be regulated.
"We are working through these to see what the way forward should be," a spokesman said. "Our response will be published as soon as possible."
Civil servant Patricia Booth, 58, took tiny brown "Xie Gan Wan" tablets for more than five years to treat a facial skin condition after being reassured that the pills were as safe as Coca-Cola.
The medicine, sold by Ying "Susan" Wu from a shop in Chelmsford, northeast of London, did clear up her skin but had disastrous consequences, the capital's Old Bailey court heard.
Months after she stopped taking the pills in 2003, she fell seriously ill, had to have her kidneys removed, contracted urinary tract cancer and later had a heart attack.
She had to quit her job managing a government office and now needs to go to hospital for dialysis three times a week.
When it was realised the pills were likely to be behind Booth's declining health, officers from the Medicines and Healthcare products Regulatory Agency (MHRA) visited the Chinese Herbal Medical Centre shop in July 2003 where Wu worked.
Wu, 48, told them she was a qualified doctor in China, but not in Britain. She was cleared of administering a noxious substance, but admitted lesser charges relating to the sale of the pills, the Press Association reported.
Judge Jeremy Roberts, who gave her a two-year conditional discharge, said the sale of traditional Chinese medicines was totally unregulated in Britain and so there was no evidence that Wu knew of tablets' potential harm.
He said he accepted Wu did not know she was breaking the law and the "last thing" she would have wanted would be for any harm to come to Booth.
"Although the MHRA did their best to try and make sure everybody knew about the dangers and about the regulations, it is not a foolproof system and I am certainly not blaming you for the fact you didn't know about these regulations," he said.
"In this country, if you are operating a business like Miss Wu's of supplying traditional Chinese medicine, there is no system in place whatever to make you aware of these regulations."
The Register of Chinese Herbal Medicine, which represents more than 450 practitioners, said the case highlighted the need for statutory regulation.
"This would ensure that anyone who practises Chinese herbal medicine is suitably qualified and competent," said Emma Farrant, secretary of the RCHM.
"It is unacceptable for the current situation to continue, whereby anyone can claim to be a Chinese medicine practitioner and put the public at risk."
The Department of Health said it received more than 5,000 responses after launching a consultation last year on whether practitioners of alternative medicine should be regulated.
"We are working through these to see what the way forward should be," a spokesman said. "Our response will be published as soon as possible."
Suzy's Safety Checklist to Use Herbal Medicine and Drugs
Dear Pharmacist, I take eight different medications and six supplements each day. I worry constantly that they will interact. Please tell your readers what some of the most common interactions are? — K.S., Decatur, Ill.
Clip this article, or forward it to someone you care for, because it just might save a life. I'm going to give you a “safety checklist” of common drug-herb interactions, and there is a huge section devoted to this in my book, “Drug Muggers.
Alcohol: The world's most famous liquid muscle relaxant, alcohol slows the heart rate down. If you combine it with sleeping pills or narcotic pain-relievers, it can stop the heart! It's also dangerous to combine it with beta blockers (blood-pressure meds).
Grapefruit: a delicious fruit that when juiced, provides powerful anti-cancer flavonoids and antioxidants. Like a few other fruits, it can block a biochemical pathway in the liver that causes the levels of medications to rise (rather than getting broken down and cleared out of the body). Some drugs that interact with grapefruit include oxycodone (Percocet), estrogen-containing hormones, most statin cholesterol drugs, sildenafil (Viagra), diazepam and some antihistamines. The interaction may occur even if you wait several hours after your medication.
Ginkgo biloba: famed for it's ability to sharpen memory by increasing blood flow to the brain. If you are taking a blood thinner, like warfarin, aspirin or Plavix, then you may experience enhanced blood-thinning effects which may lead to easy bruising and internal bleeding.
Pomegranate or grapefruit juice: Chock full of antioxidants and heart-healthy nutrients, but it might spike the level of sex pills (Cialis, Levitra or Viagra) causing headache, indigestion, flushing, heart palpitations or visual disturbances.
Stinging nettle: It helps men with prostate problems and women with overactive bladder. Thing is, it has this lovely benefit of slightly lowering blood sugar. If you take stinging nettle while also taking diabetic medication, your blood sugar may drop too low so monitor carefully or avoid the herb.
Iron or zinc supplements: Wonderful to help improve immunity and rev up thyroid production, but these can block the actions of many popular antibiotics including Cipro and Levaquin.
St. John's wort: Fantastic for boosting mood and reducing pain. It can increase levels of other drugs, causing them to spike so high that you get dangerous side effects. This doesn't mix well with digoxin, omeprazole (Prilosec), MAO anti-depressants, oral contraceptives, alprazolam (Xanax), and drugs used for HIV/AIDS.
Ginseng, ma huang or bitter orange, caffeine: Found in many diet pills, these stimulate the body so avoid if you take breathing medications such as inhalers (bronchodialators) or theophylline.
Arginine: Very popular natural amino acid that helps erectile dysfunction and improves blood flow to the heart. It's wonderful that arginine also reduces blood pressure, but if you take this with nitroglycerin or isosorbide drugs, it can result in dangerously low blood pressure.
Clip this article, or forward it to someone you care for, because it just might save a life. I'm going to give you a “safety checklist” of common drug-herb interactions, and there is a huge section devoted to this in my book, “Drug Muggers.
Alcohol: The world's most famous liquid muscle relaxant, alcohol slows the heart rate down. If you combine it with sleeping pills or narcotic pain-relievers, it can stop the heart! It's also dangerous to combine it with beta blockers (blood-pressure meds).
Grapefruit: a delicious fruit that when juiced, provides powerful anti-cancer flavonoids and antioxidants. Like a few other fruits, it can block a biochemical pathway in the liver that causes the levels of medications to rise (rather than getting broken down and cleared out of the body). Some drugs that interact with grapefruit include oxycodone (Percocet), estrogen-containing hormones, most statin cholesterol drugs, sildenafil (Viagra), diazepam and some antihistamines. The interaction may occur even if you wait several hours after your medication.
Ginkgo biloba: famed for it's ability to sharpen memory by increasing blood flow to the brain. If you are taking a blood thinner, like warfarin, aspirin or Plavix, then you may experience enhanced blood-thinning effects which may lead to easy bruising and internal bleeding.
Pomegranate or grapefruit juice: Chock full of antioxidants and heart-healthy nutrients, but it might spike the level of sex pills (Cialis, Levitra or Viagra) causing headache, indigestion, flushing, heart palpitations or visual disturbances.
Stinging nettle: It helps men with prostate problems and women with overactive bladder. Thing is, it has this lovely benefit of slightly lowering blood sugar. If you take stinging nettle while also taking diabetic medication, your blood sugar may drop too low so monitor carefully or avoid the herb.
Iron or zinc supplements: Wonderful to help improve immunity and rev up thyroid production, but these can block the actions of many popular antibiotics including Cipro and Levaquin.
St. John's wort: Fantastic for boosting mood and reducing pain. It can increase levels of other drugs, causing them to spike so high that you get dangerous side effects. This doesn't mix well with digoxin, omeprazole (Prilosec), MAO anti-depressants, oral contraceptives, alprazolam (Xanax), and drugs used for HIV/AIDS.
Ginseng, ma huang or bitter orange, caffeine: Found in many diet pills, these stimulate the body so avoid if you take breathing medications such as inhalers (bronchodialators) or theophylline.
Arginine: Very popular natural amino acid that helps erectile dysfunction and improves blood flow to the heart. It's wonderful that arginine also reduces blood pressure, but if you take this with nitroglycerin or isosorbide drugs, it can result in dangerously low blood pressure.
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